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6 All participants in studies 1 and 2 were instructed to follow a reduced-calorie diet (with a deficit of approximately 500 kcal/day) and received counseling on increased physical activity (recommended minimum of 150 min/week) starting from the commencement of the study medication or placebo continuing throughout the trials.Study 1 enrolled 2539 adult patients with obesity or overweight and at least 1 weight-related comorbid condition, except for patients with type 2 diabetes

Furthermore, research suggests that GLP-1 RAs confer a range of advantages to individuals without diabetes but with CVD

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doi:10.1007/s11055-016-0377-8 31

PMID 3374544