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Start low, even coming from a high dose Most switch protocols start tirzepatide at 2.55 mg/week regardless of the semaglutide dose someone was previously on, then re-titrate from there to limit GI side effects

Some practitioners recommend 2 to 3 mg administered several times weekly rather than daily dosing

Proactive probiotic support helps maintain microbial diversity and gut barrier function, potentially preventing problems before they develop

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Because the condition has a distinct appearance, additional testing is rarely necessary