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Diabetes 54 , 146151 (2005)
Winterbourn CC, Hampton MB
Antioxid (Basel) (2021) 10:1175
Tirzepatide was developed as a unimolecular dual agonist and moved through the SURPASS (type 2 diabetes) and SURMOUNT (obesity) Phase 3 programs to approval, becoming the first approved GLP-1/GIP dual agonist
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Their mechanisms enhance insulin sensitivity, reduce hepatic fat synthesis, improve lipid metabolism, and alleviate steatosis (Yabut and Drucker, 2023)
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