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GLP-1RA/tesaglitazar (50 nmol kg 1 per day) also led to a greater decrease in body weight and food intake relative to DIO mice treated with a fixed dose combination of the GLP-1RA and tesaglitazar (Extended Data Fig

And yes, there is a cost associated with it

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For many people taking a GLP-1 is less about the promise of the drug itself and more about whether the health care system can support them long enough for that promise to hold

However, reports have raised concerns about the potential association between these medications and an increased risk of depression and suicidal ideation