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The upregulated Pt transporters [e.g., organic cation transporters (OCTs), multidrug and toxin extrusion proteins (MATEs), and copper transporters 1/2 (Ctr1/2)] in DGR increase the accumulation of Pt drugs in peripheral nerves as the first step to induce PIPN (Sprowl et al., 2013

This has motivated therapeutic strategies that modulate proteostasis to recalibrate immune responses rather than solely suppress downstream inflammation

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Compounded HRT becomes clinically relevant when FDA-approved options are insufficient for a specific patients situation

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Integrate with Comprehensive Care BPC-157 should be used as part of a broader approach to managing back pain