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Figure 13 summarizes key intracellular glutathione (GSH) sensing strategies, encompassing fluorescent probes that detect reduced GSH through light emission, enzymatic biosensors that generate electrical signals via GSHNAD(P)H redox cycling, quantum nanoprobes that enable high-resolution fluorescence shifts, and nanomaterial-based sensors that act as GSH-responsive reporters for gene editing and signal amplification
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It's important to discuss your options with a physician, try different combinations and doses to see how your body reacts, and adjust your dosages to fit your needs and your goals
Recent findings Recent studies on over 13 000 healthy blood donors, as part of the Recipient Epidemiology and Donor Evaluation Study (REDS) III and IV-P RBC omics, and 525 diversity outbred mice have highlighted the impact on RBC metabolism of biological factors (age, BMI), genetics (sex, polymorphisms) and exposure (dietary, professional or recreational habits, drugs that are not grounds for blood donor deferral)
Similar content being viewed by others Log in or create a free account to read this content Gain free access to this article, as well as selected content from this journal and more on nature.com or Abbreviations GSH: reduced glutathione GSSG: glutathione disulfide GS: thyil radical ROS: reactive oxygen species RNS: reactive nitrogen species RS: reactive species -GCS: -glutamylcysteine synthetase GPX: glutathione peroxidase GR: glutathione reductase GST: glutathione S -transferase GSNO: nitrosoglutathione G6PD: glucose-6-phosphate dehydrogenase NAC: N -acetyl-L-cysteine NO: nitric oxide protein-SSG: protein glutathionylation protein-SNO: protein nitrosylation References Galluzzi L, Maiuri MC, Vitale I, Zischka H, Castedo M, Zitvogel L et al
Test compounds were administered subcutaneously following a 2 h fast on day 0
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