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This week, Novo Nordisk announced that people taking its mega-dose version of semaglutide lost substantially more body weight than usual in a large-scale trial

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In our experience working with first responder patients, weve found that adherence to protocol and regular follow-up appointments correlate directly with positive outcomes

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To assess whether these trends reflected coordinated biochemical changes rather than isolated metabolite fluctuations, we performed pathway-level analysis comparing shunt responders and non-responders ( Figure 2C )