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Read review Dihexa for Lewy Body Dementia CervoMed neflamapimod Phase 2b/3, alpha-synuclein seed amplification, and 100,000 UK DLB patients
Notably, breast cancer cells achieve metabolic adaptation by hijacking the autophagy mechanism: under glucose-deprivation conditions, MANF-mediated mitophagy eliminates dysfunctional mitochondria through the PRKN/Parkin-dependent pathway, maintains the ATP supply and promotes tumour survival [112], suggesting that targeting the MANFPRKN interaction can break the drug resistance barrier of breast cancer under metabolic stress
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