00:26:04 Jennifer Trujillo I dont feel like I have a great answer because I do feel like we talk about it in clinical practice, but Im not completely convinced that its due to something like GLP-1 receptor downregulation or something like that
If you expect overnight and mega alterations, then be prepared for letdown
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Anticipated Costs Post-Approval While neither compound has reached market, pricing for similar medications provides context: Semaglutide (Wegovy) Approximately $1,300-$1,500 monthly without insurance Tirzepatide (Zepbound) Approximately $1,000-$1,200 monthly without insurance Cagrilintide and retatrutide would likely fall in similar price ranges, with combination therapy potentially costing $2,000-$3,000 monthly without insurance coverage