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The Dysesthesia Safety Signal The most-discussed Phase 3 finding has been dysesthesia abnormal skin sensations including tingling, burning, or pricking reported at 20.9% incidence at the 12 mg dose versus 0.7% on placebo in TRIUMPH-4

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Because retatrutide is still an investigational compound, there are currently no published pharmacokinetic or pharmacodynamic interaction studies examining its combination with sermorelin

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