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Tirzepatide, compared to both GLP-1 and NNC0090-2746, shows biased signaling at GLP-1R, favoring cAMP response over -arrestin recruitment, which leads to low efficacy for GLP-1R internalization (108110)
Same total intake, dramatically better tolerance
Most children do very well with outdoor activities and exercise
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131 StambolijaV.StambolijaT
doi: 10.3389/ftox.2025.1687862 Received 03 September 2025 Revised 15 October 2025 Accepted 17 October 2025 Published 24 November 2025 Corrected 16 February 2025 Volume 7 - 2025 Edited by Ahmed Elsayed Noreldin, Damanhour University, Egypt Reviewed by Thomas Hofmann, Thomas Hofmann Toxicological Consulting (THC), Germany Juman Khaleel Al-Sabbagh, University of Kerbala, Iraq Updates Copyright 2025 Okon, Fasogbon, Swase, Dangana, Makena, Ojiakor, Etukudo, Chebet, Musyoka, Ifie, Mbyemeire, Mbina, Ugwu, Oviosun, Usman, Ifie, Rangasamy, Olorunnisola, Mounmbegna, Noreen and Aja
