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Interestingly, the presence of tamoxifen and rotenone together produced the largest growth inhibitory effects on CHO R C5 that were reversed with the addition of NAC (0.5 mM) which increases reduced-thiols levels or PSC-833 (2 M), an inhibitor of P-gp-ATPase activity (Fig

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In contrast to chronic treatment with intact hGH, chronic treatment with AOD9604 showed no adverse effect on insulin sensitivity of the animals, as demonstrated with euglycemic clamp techniques Another study published in 2001 found the same thing, yet the results were very different for lean rats versus obese rats: Both hGH and AOD significantly reduced body weight gain in obese mice