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To determine the content of TBCRS, 2.4 mL of a 0.07 N sulfuric solution and 0.3 mL of a 10% solution of phosphotungstic acid are sequentially added to the test sample of 10% brain homogenate (0.3 mL)

372 PLGA-PEG nanoparticle-based systems efficiently deliver HECTD2 inhibitors or KEAP1 stabilizers to inhibit HECTD2-mediated KEAP1 degradation, restoring KEAP1/NRF2 balance, suppressing antioxidant responses, and reversing lenvatinib resistance in HCC