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A significant limitation of the current clinical evidence is its reliance on post-hoc analyses of cardiovascular outcome trials and large-scale retrospective studies

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A schematic diagram illustrating the diverse pain modalities and their associated mechanisms is presented in Fig

Determining the best animal model for human cytochrome P450 activities: a comparison of mouse, rat, rabbit, dog, micropig, monkey and man

Under oxidative stress these three systems work in concert to detoxify ROS and lipid peroxides, maintain protein structure and function via thiol repair, prevent activation of redox-sensitive inflammatory pathways, and preserve mitochondrial membrane integrity and prevent apoptosis