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However, the collected body of evidence does not fully support its clinically relevant antidepressant benefit [165]
Tirzepatide was titrated up to a maximum maintenance dose of 15 mg weekly according to the approved label
Food and Drug Administration (FDA) include: semaglutide (Ozempic, Wegovy, Rybelsus) tirzepatide (Mounjaro, Zepbound) liraglutide (Victoza, Saxenda) dulaglutide (Trulicity) exenatide (Byetta, Bydureon) lixisenatide (Adlyxin) Each works a bit differently and is FDA-approved for different uses
doi: 10.1210/jc.2015-3272 39 WilliamsKVErbeyJRBeckerDArslanianSOrchardTJ
However, retatrutide is a first-in-class triple agonist (targeting GIP, GLP-1, and glucagon receptors simultaneously), which may lead to more cautious FDA review compared to drugs with established mechanisms
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