The GLP-1 RAs appear to modify atherosclerosis in the arteries, much like statin medications that treat cholesterol, and takes about a year or more to demonstrate measurable benefits on risk for cardiovascular events, whereas the SGLT2i medications seem to affect heart and kidney function more prominently and faster, with benefits evident very soon after starting the medication
Stern JH, Smith GI, Chen S, Unger RH, Klein S, Scherer PE
Stronger, more functional tissue in as little as 14 days in animal models
Semaglutide might be leaving you dragging for a bunch of reasonssome are directly tied to how the medication works, while others might be sneaky lifestyle changes you didn't even realize you were making

Supplement Facts: Serving Size: 1 Scoop (13.3g) Servings Per Container: 30 Amount Per Serving: L-Citrulline DL-Malate 2:1: 6g Beta-Alanine: 3.2g Beet Root Extract (1% Nitrate): 1g Taurine: 1g Caffeine Anhydrous: 250mg AMPiberry (Juniperus communis): 150mg Infinergy (Di-Caffeine Malate): 100mg Cocoteanol (Theobroma cacao & Camelia sinensis extract): 50mg Naringin 98% (Citrus grandis): 25mg Bioperine (Black Pepper extract): 10mg Calories: 0 kcal Energy kJ: 0 kJ Protein: 0g Carbohydrate: 0g of which sugars: 0g Fat: 0g of which saturates: 0g Fibre: 0g Salt: 0g *RI - Reference Intake Ingredients: L-Citrulline DL-Malate 2:1, Beta-Alanine, Beet Root Extract (1% Nitrate) (Beta vulgaris), Taurine, Caffeine Anhydrous, AMPiberry (Juniperus communis) (berry), Infinergy (Di-Caffeine Malate), Cocoteanol (Theobroma cacao & Camelia sinensis extract), Naringin 98% (Citrus grandis) (fruit), Bioperine (Black Pepper extract) (fruit), Silica, Natural and Artificial Flavoring, Calcium Silicate, Sucralose, Acesulfame Potassium

NRF2 prevents ROS and oxidative stress