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Importantly, the role of PKA in activating multiple downstream targets involved in prosurvival signaling (eNOS, AKT) is well established (4, 21, 5054)

This explains both its greater effectiveness and more convenient dosing schedule

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All clinical data cited reflects publicly disclosed trial results and FDA labeling

Repeatedly injecting into the same small area can cause lipohypertrophy, which is a buildup of fatty tissue that can interfere with how the medication is absorbed

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