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Regulatory note: The FDA added injectable GHK-Cu to a high-risk compounded substance list in September 2023

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BPC-157 is a 15-residue, 1419.53 g/mol pentadecapeptide whose mechanistic literature centres on local angiogenic signalling, Hsieh and colleagues (J Mol Med, 2017) reported upregulation and internalisation of VEGFR2 in human endothelial cells, and Chang and colleagues (J Appl Physiol, 2011) reported increased FAK and paxillin phosphorylation with greater outgrowth and migration in cultured rat tendon fibroblasts

Given that ghrelin should not be produced during the fed state, it is unlikely that it modulates insulin secretion associated with the postprandial period

Both supplements are useful, but they support different goals

A: Its best taken after a morning meal daily