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ROS exert cellular toxicity by modifying DNA, lipids, and proteins through DNA base oxidation, lipid peroxidation, and protein carbonylation (protein oxidation), respectively 7,8,9

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In particular, changes in alcohol and nicotine use (both directly affecting sedation and recovery) may be more common than expected but not always captured in routine documentation

The chemicals in cigarettes can cause your lips to darken, and over time, the discoloration can become permanent