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For example, exendin-4 lowers very-low-density lipoprotein cholesterol (VLDL-C) and LDL-C in animal models by reducing hepatic sterol regulatory element-binding protein 2 (SREBP2) levels and cholesterol absorption (88)
The treatment protocol typically involves a step-up approach, starting with a low dose and gradually increasing it to a maintenance dose
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15 Unlike the U.S
Physiological and pathological oral mucosal melanin hyperpigmentations may be similar in appearance, and sometimes may be difficult to differentiate even on the basis of history and microscopical features
