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Troth SP, Simutis F, Friedman GS, Todd S, Sistare FD (2019) Kidney SAFETY ASSESSMENT: CURRENT PRACTICES IN DRUG DEVELOPMENT
Belly fat can lower testosterone because fat tissue contains aromatase, an enzyme that converts testosterone into estrogen
OBSCN gene variants have been previously implicated in inherited cardiomyopathies and, more recently, biallelic loss-of-function variants have been implicated in causing exercise intolerance, rhabdomyolysis, and myoglobinuria without any evidence of concomitant cardiomyopathy in nine unrelated patients (116
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Participants with BMI under 35 had higher dropout rates, sometimes due to perceived excessive weight loss. For participants with BMI 35 (the primary target population for this medication), discontinuation rates were 8.8-12.1%, more comparable to other weight loss medications
