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Tesofensine works centrally: it prevents monoamine transporters from clearing neurotransmitters from the synapse, extending their signalling duration and intensity

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One trial included healthy non-obese participants, demonstrating that the favorable safety profile was not unique to obese individuals

SS-31 (Elamipretide): The Mitochondrial Repair Agent What it does: SS-31 targets the inner membrane of mitochondria, reducing oxidative stress and boosting ATP production

The incretins have far stronger and more mature human clinical data

AOD9604 (anti-obesity drug 9604) is a peptide linked to weight loss