Consequently, simulations suggest that while doxorubicin redox metabolism impacts GSH metabolism, the concentrations required to illicit a toxic response, with either a single or extended exposure, reside outside that of the therapeutic dosing range
[6] [25] At levels only slightly below normal, deficiency can result in fatigue, headaches, feeling faint, rapid breathing, pale skin, numbness or tingling, poor appetite, heartburn, poor balance, difficulty walking, poor reflexes, blurred vision, memory problems, depression, irritability, inattention, cognitive decline, dementia, and even psychosis
Dry mouth itself is not dangerous, but the downstream effects on oral health can be serious if unmanaged
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doi:10.1038/s41591-018-0222-4 10
doi: 10.1016/j.scienta.2015.03.023 73 SularzO.KoronowiczA.SmoleS.KowalskaI.Skoczylas.Liszka-SkoczylasM