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This lack of signal in controlled settings provides some reassurance, though it does not definitively exclude the possibility of effects in individual patients or specific subpopulations

These medications mimic hormones that control appetite and insulin production

Over the past three decades, angiotensin-converting enzyme (ACE) inhibitors and angiotensin receptor blockers (ARBs) established renin-angiotensin-aldosterone system (RAAS) blockade as the cornerstone of DKD management [7,8]

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