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Gier B, Matveyenko AV, Kirakossian D, Dawson D, Dry SM, and Butler PC

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When food intake drops too far, the body may not be getting enough nutrients to support muscle preservation or metabolic function and it can worsen constipation at the same time

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The gut microbiome composition may influence GLP-1 production through SCFA generation and bile acid metabolism

63 In addition to their benefits on quality of life in HFpEF, further randomised trials are needed to effectively assess the effects of GLP-1 RA on harder clinical outcomes