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Malaysian J

Current guidelines, such as those from the European Society of Cardiology (ESC), recommend the use of SGLT-2i as a first-line treatment in patients with T2DM with multiple atherosclerotic cardiovascular disease (ASCVD) risk factors, established ASCVD, patients with T2DM and HFrEF to reduce the risk of heart failure hospitalization and cardiovascular death [13]

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The most commonly reported adverse events are gastrointestinal reactions, including nausea, vomiting, diarrhea, and constipation, which typically occur during the early phase of treatment and tend to diminish or resolve with continued therapy (55, 56)

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Strengths S1: Balanced receptor pharmacology