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Sleep deprivation also increases cortisol levels, which promotes muscle breakdown and fat storage
Key trials demonstrate: SUSTAIN-1 : HbA1c reduction ~1.45-1.55% with modest weight loss (~3.734.53 kg )
Bradley KAL, Case JAC, Khan O, Ricart T, Hanna A, Alonso CM, et al
But it typically results in shorter, more conservative BUDs
however, retatrutide has not received marketing authorisation from the Medicines and Healthcare products Regulatory Agency (MHRA) or the European Medicines Agency (EMA), and it is not approved for clinical use in the UK
While possible, maintaining results after stopping GLP-1 therapy is challenging and requires intensive lifestyle modifications including 200-300 minutes of weekly exercise, consistent dietary changes, regular self-monitoring, and often ongoing behavioral support
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