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While tirzepatide preserves lean mass better than diet alone, some researchers look for ways to further protect muscle during aggressive weight loss

NNMT transfers a methyl group from SAM onto nicotinamide, producing 1-methylnicotinamide while consuming methyl donors and contributing to NAD depletion

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Unlike other peptides, which primarily work through appetite suppression and metabolic regulation, these peptides go deeper, supporting mitochondrial function, enhancing fat oxidation, increasing muscle protein synthesis, and even reversing aspects of cellular aging

These findings suggest oral administration can be effective, at least in rodent models