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Retatrutide adds the glucagon receptor as a third target, and that third receptor is the differentiator

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In a large clinical trial, people on the highest dose of Ozempic (2 mg weekly) lost an average of about 15 pounds, roughly 7% of their body weight , over 40 weeks

Obesity Reviews, 2010

DAPA-HF (Dapagliflozin and Prevention of Adverse Outcomes in Heart Failure) revealed that the use of dapagliflozin in patients with New York Heart Association (NYHA) class II, III, or IV heart failure and an ejection fraction of 40% resulted in a lower risk of worsening heart failure and cardiovascular death