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Safety vigilance, thoughtful patient selection, and integration with behavioural care are the practical requirements for translating trial efficacy into real-world benefit

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all GLP-1 and GIP-receptor agonists carry a black-box warning for thyroid C-cell tumors in animal models, though human thyroid cancer risk remains unproven

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Before each use, take a quick look at the liquid if it's cloudy, has particles, or looks discolored, don't use it.

Earlier initiation may be appropriate when significant comorbidities persist, but timing should be individualized based on surgical procedure type and metabolic status