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The bone loss is likely from rapid weight loss, not the drug itself
This review integrates current evidence on how brain peptides contribute to AD pathophysiology, summarizes recent progress in peptide-based therapeutic strategies and delivery platforms, and critically examines the remaining barriers to clinical translation, including bloodbrain barrier penetration, metabolic stability, off-target effects, and the need for biomarker-guided patient stratification
The plaque load in the cortex and the chronic inflammatory response were also reduced ( Novel dual- Glucagon-like peptide 1/glucose-dependent insulinotropic peptide receptor agonists are protective in animal models of Alzheimers disease The dual-receptor agonist DA3-CH that does not have any modifications, such as acylation to increase the survival time in the blood, enters the brain easier and shows good neuroprotective effects in the APP/PS1 mouse model
Yesavage, A
Could be the medication
As a result Novo Nordisk and the National Institutes of Health funded a randomised, double-blind, controlled trial to look at the issue
