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What is clear is that factors such as UV exposure and immunosuppression also play a role

Further studies revealed that GLC increases melanin production in melanocytes by three pathways, 1) activating activator protein-1 (AP-1) and CRE promoter to activate p42/44 MAPK signaling, 2) activating cAMP signaling, and 3) decreasing GSK3 phosphorylation while inducing CREB phosphorylation (Lee et al., 2005)

One such mechanism occurs within immune cells, which require sufficient glutamine as a substrate for leukocyte function, cell proliferation, tissue repair, and intracellular pathogen recognition pathways

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The relationship between progressive multifocal leukoencephalopathy and GSH still remains unknown

Silva AM, Barbosa FHF, Duarte R, Vieira LQ, Arantes RME, Nicoli JR (2004) Effect of Bifidobacterium longum ingestion on experimental salmonellosis in mice