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Andrea Schroeder is specialist nurse and director, Tailor Clinics, Hamilton, New Zealand

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Definition and Scope 1.2

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Common gastrointestinal side effects include: Nausea often most pronounced when starting treatment or increasing the dose, typically improving over time Diarrhoea may occur intermittently, particularly in the first few weeks Vomiting less common than nausea but can occur, especially if doses are increased too rapidly Constipation some patients experience this rather than diarrhoea Abdominal pain or discomfort usually mild to moderate Decreased appetite whilst this contributes to weight loss, some patients find it excessive Indigestion or dyspepsia These gastrointestinal effects are generally mild to moderate in severity and tend to diminish as your body adjusts to the medication