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The same results were found in osteosarcoma cells and breast cancer cells
![tirzepatide surpass-5 Changes in HbA1c from baseline to end of treatment in SURPASS 1-5 [10-14] surpass 5 tirzepatide EASD2021 #type2diabetes](https://pbs.twimg.com/media/FAWydfmWEAIHYal.jpg)
If DEXA scans arent accessible, bioelectrical impedance devices or even waist measurements can help track changes
![tirzepatide surpass-5 Changes in HbA1c from baseline to end of treatment in SURPASS 1-5 [10-14] surpass 5 tirzepatide EASD2021 #type2diabetes](https://media.springernature.com/m685/springer-static/image/art%3A10.1007%2Fs40265-022-01746-8/MediaObjects/40265_2022_1746_Figa_HTML.png)
The body begins to look more athletic and proportioned
![tirzepatide surpass-5 Changes in HbA1c from baseline to end of treatment in SURPASS 1-5 [10-14] surpass 5 tirzepatide EASD2021 #type2diabetes](https://m3.healio.com/~/media/slack-news/endocrinology/infographics/et0222dahl_mm_graphic_01_web.jpg)
Creatine supplementation effects on lean mass and strength
![tirzepatide surpass-5 Changes in HbA1c from baseline to end of treatment in SURPASS 1-5 [10-14] surpass 5 tirzepatide EASD2021 #type2diabetes](https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs12933-023-01797-5/MediaObjects/12933_2023_1797_Fig1_HTML.png)
For 3 months
![tirzepatide surpass-5 Changes in HbA1c from baseline to end of treatment in SURPASS 1-5 [10-14] surpass 5 tirzepatide EASD2021 #type2diabetes](https://image.slidesharecdn.com/type2diabetes-221209190316-3275c6ea/85/Type-2-diabetes-pptx-26-320.jpg)
However, sublingual (under-the-tongue) formulations present unique challenges for absorption and bioavailability that may limit their real-world effectiveness compared to standard injection protocols
![tirzepatide surpass-5 Changes in HbA1c from baseline to end of treatment in SURPASS 1-5 [10-14] surpass 5 tirzepatide EASD2021 #type2diabetes](https://cdn.sanity.io/images/0vv8moc6/ajmc/98a1293ad49521b266661810b757e81d0b87969b-800x532.jpg?w=350&fit=crop&auto=format)
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