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According to the National Health and Medical Research Council (NHMRC), the recommended dietary intake of vitamin B12 for men and women above 18 years is 2.4 ug/day

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[78] found that Lira inhibited proprotein convertase subtilisin/kexin type 9 (PCSK9) expression in HepG2 cells and db/db mice through hepatocyte nuclear factor 1 (HNF1)-dependent mechanism, and may inhibit LDLR expression in db/db mice through PCSK9 independent pathway, and ultimately reduce liver cholesterol accumulation