Phase 2 data showed up to 24.2 percent body weight loss in 48 weeks versus semaglutide's 14.9 percent in 68 weeks, suggesting potentially faster and greater weight loss
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Gastrointestinal side effects, including nausea, vomiting, diarrhea, and constipation, are common with GLP-1 receptor agonists
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DPP-4 inhibitors increase endogenous GLP-1, and GLP-1 receptor agonists directly stimulate the receptor
Zepbound may offer greater weight loss benefits for some individuals, but both medications have similar side effects, such as nausea and gastrointestinal discomfort