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Furthermore, it has been reported that tenocytes with IGF-1 (10, 50, and 200 ng/mL) displayed the increased expression of tenocyte-associated structural protein genes for type I collagen (COL1A2), and type III collagen (COL3A1), but this effect is not dose-dependent and highest values were achieved at 50 ng/mL (Caliari and Harley, 2013)

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Safety and efficacy of S-adenosylmethionine (SAMe) for osteoarthritis

10.1530/jrf.0.1080041 233

Media supplemented with SOD and CAT enzymes reversed 8-OH-2-dG DNA modifications and prevented morphological anomalies

However, each additional compound adds variables