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However, repeated intramuscular injections over multiple weeks could theoretically affect overall treatment outcomes

These direct effects are further supported by human studies demonstrating the wide expression of GLP-1 receptors in the proximal tubules, juxtaglomerular cells, hilar and intralobular arteries, and preglomerular vascular smooth muscle cells [49]

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[28] suggest that patients who omitted at least one dose of their GLP-1RA prior to surgery had a lower risk of RGC compared to those maintained on a regular dosing regimen

19% of Americans have used a GLP-1 medication