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In a comparative study for type 2 diabetes, semaglutide lowered A1C levels by about 1% to 2%, while tirzepatide lowered A1C by 2% to 2.5%.In a head-to-head comparative study looking at weight loss, average weight loss was 50.3 lbs (22.9 kg) with tirzepatide compared to 33.1 lbs with semaglutide Weight loss with tirzepatide may be superior to semaglutide, but this can vary among patients