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The D-Retro-Inverso modification (using D-amino acids in reverse sequence) provides resistance to proteolytic degradation while maintaining the ability to interfere with the target protein interaction

10.1038/s41380-020-0645-4 Mol Psychiatry

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Abstract Intrinsically disordered proteins such as amyloid- (A), prion protein (PRP) and -synuclein bind copper-ions through histidine-rich motifs