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Clinical trial data from the Phase 2 studies showed participants losing an average of 24.2% of their body weight over 48 weeks at the highest dose
Common safety concerns include gastrointestinal side effects and heart rate increases for retatrutide, and glucose metabolism changes and fluid retention for tesamorelin
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(Source) Intestinal obstructions: One study found that participants who took an incretin-based drug (e.g, a GLP-1 like Ozempic) were over 4.5 times more likely to report having an intestinal obstruction than those taking other diabetes medications
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