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Lifestyle modification is the most effective intervention currently available and is strongly recommended by NICE

However, this explanation would not be expected to apply to the wild type

Based on available clinical data, retatrutide produced significantly greater weight loss (-24.2% at 48 weeks) than semaglutide (-16.0% at 68 weeks) in their respective trials

10.1111/j.1471-4159.2006.04393.x 69