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Both have little clinical evidence behind them, however
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IGF1R-6 integrin-S100A4 network governs the organ-specific metastasis of chemoresistant epithelial ovarian cancer cells
They result from a combination of factors such as decreased collagen and elastin production, loss of hydration, and cumulative damage from environmental factors like UV exposure
Together these three 1998 papers form the primary-source foundation cited throughout the later literature
Psychiatry 12:671151
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