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(44) was about 20% higher than the maximum in the previously published results of our study (12), a faster cortisol-induced down-regulation of APR could have resulted in an earlier reduction of IL-6

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ATM-deficient mice, worms, and cell models demonstrated accumulation of cytoplasmic DNA, hyperactivation of PARP1, and low NAD + levels 111,288

The role of OS in ALS pathology, whether as a primary cause of disease or a secondary consequence, is now well recognized and many preclinical and clinical studies have consistently demonstrated that the disease is characterized by high levels of OS markers able to induce cellular damage, impaired cell signalling, and finally cell death [25, 86]

As weve mentioned, CR decreases NADH (in yeast), which increases (i.e, improves) the NAD + : NADH ratio