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These are not identical studies, so cross-trial comparison should be treated as directional rather than definitive
Glucagon also stimulates energy expenditure
Low-dose naltrexone is not a peptide, but it has the strongest human evidence in this space
In summary, the reprogramming of hepatocytes associated with a profibrotic milieu results in loss of mature parenchymal cells, characterized by loss of the master hepatocyte transcription factor HNF4 (158, 212) and upregulation of the developmental Notch, Hippo (213), and Hedgehog (214) signaling pathways
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