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The effect is almost exclusively from the CJC-1295 component of the stack
At Klarity Health, we often remind our patients that this first week is about adaptation, not results
Int J Mol Sci 23(2): 739
Although these changes in HR upon GLP-1 RA administration were subtle and the underlying mechanisms are unclear, further studies are necessary to elucidate the long-term effects of GLP-1 RAs primarily on HR and other related variables to clarify whether the elevated HR can be regarded as a transient reflex mechanism or whether it might in fact lead to poor cardiovascular outcomes in a diabetic population
Lastly, the primary end point in PIONEER 6 (the CVOT) was a time to event analysis
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