In the Phase 3 obesity trial, rates were about 5%, 12%, and 13% at 4, 9, and 12 mg
This is the same trick used in tirzepatide and retatrutide, which is why all three share an Aib at that position and why noticing it is the fastest way to place an unfamiliar incretin analog structurally
As with any therapeutic compound, application under physician guidance is recommended to ensure appropriate concentration and formulation
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(1) Abdel-Malek Z, Swope VB, Suzuki I, Akcali C, Harriger MD, Boyce ST, Urabe K, Hearing VJ