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This approach fundamentally reimagines platinum anthracycline combination regimens by consolidating two mechanistically distinct cytotoxic agents within a single intelligent nanocarrier that autonomously senses and responds to TME metabolic signatures, eliminating the need for complex dosing schedules and pharmacokinetic optimization while minimizing cumulative cardiotoxicity and nephrotoxicity associated with systemic platinum and DOX coadministration (Fig

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The Congressional Budget Office (CBO) has been working to provide information to Congress on the potential for preventive medical carewhich could include obesity treatmentto save money