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You should not take Semaglutide if you have diabetic retinopathy, personal or family history of medullary thyroid carcinoma, multiple endocrine neoplasia type 2, trying to get pregnant or are pregnant, breast-feeding, or have depression with a history of suicidal thoughts

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Research has not demonstrated significant differences in efficacy between morning and evening administration for once-daily or once-weekly formulations, provided the medication is taken regularly