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Saitoh M, Nishitoh H, Fujii M, Takeda K, Tobiume K, Sawada Y, Kawabata M, Miyazono, K and Ichijo H

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Consistency matters because receptor expression is rhythmic, not because the peptide cares what time it is

Tissue-targeted delivery or isoform-biased agonists may improve therapeutic index where cardiometabolic benefit is desired with minimal off-target receptor engagement

The role of GSH metabolism in cell differentiation, proliferation and apoptosis has been previously shown to lead to cancer progression and chemoresistance 21

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